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At one point zyban accounted for 25 of all mhra yellow card adverse drug reactions in the uk.
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The nicotine inhaler and bupropion zyban joined as prescription products in 1997.
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Two studies with bupropion sr 150mg tablets in healthy volunteers suggest that exposure to bupropion may be increased when zyban tablets are taken with food.
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data from a comparative trial of zyban, nts, the combination of bupropion plus nts, and placebo as an aid to smoking cessation suggest a higher incidence of treatment-emergent hypertension in patients treated with the combination of bupropion and nts.